Virus neutralizing MAb binding and T helper cell stimulating peptide epitopes from structural and nonstructural proteins of Japanese encephalitis virus were delineated. It was observed that priming by T helper peptides potentiated neutralizing antibody response against JE virus. Immunization with chimeric T helper - B cell peptides could thus protect mice from lethal challenge with JE virus.
Keywords: Japanese encephalitis virus, MAb binding peptides, Neutralising antibodies, Chimeric Th-B cell peptides, immunopotentiation, Peptide vaccine
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