Characterization of Antibody-Binding Sites on Proteins: Development of a Knowledgebase and Its Applications in Improving Epitope Prediction

Author(s): A.D. Ghate, B.U. Bhagwat, S.G. Bhosle, S.M. Gadepalli, U.D. Kulkarni-Kale.

Journal Name: Protein & Peptide Letters

Volume 14 , Issue 6 , 2007

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Abstract:

Immunoinformatics provides tools for reverse vaccinology and encompasses development of knowledge bases and algorithms for prediction of epitopes. AgAbDb, a database archiving molecular interactions of antigen-antibody cocrystal structures, has been developed (http://202.41.70.51:8080/agabdb2/). Analyses of antibody-binding sites on proteins helped to fine-tune the parameters for prediction of sequential and conformational B-cell epitopes.

Keywords: Immunoinformatics, Bioinformatics, conformational or discontinuous epitope, B-cell epitope prediction, antigenantibody interactions, derived database

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Article Details

VOLUME: 14
ISSUE: 6
Year: 2007
Page: [531 - 535]
Pages: 5
DOI: 10.2174/092986607780989921
Price: $58

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