Prediction of B Cell and T Cell Epitopes of DBLα Domain in Plasmodium falciparum Malaria Vaccine Candidate Var Gene

Author(s): Aarti D. Ozarkar, D. Prakash, Dileep N. Deobagkar, Deepti D. Deobagkar.

Journal Name: Protein & Peptide Letters

Volume 14 , Issue 6 , 2007

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Abstract:

P. falciparum encodes PfEMP-1 which is important in pathogenicity and virulence. We have analyzed the structure of the Duffy binding like (DBLα) domain of var genes and predicted the antigenic sites and T and B cell epitopes which present a highly variable picture with major implications in immune interactions and vaccine design.

Keywords: malaria, PfEMP1, var, epitopes, antigenic sites

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Article Details

VOLUME: 14
ISSUE: 6
Year: 2007
Page: [528 - 530]
Pages: 3
DOI: 10.2174/092986607780989967
Price: $58

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