The Tumor Necrosis Factor-Derived TIP Peptide: A Potential Anti-Edema Drug

Title: The Tumor Necrosis Factor-Derived TIP Peptide: A Potential Anti-Edema Drug

Volume: 4 Issue: 5

Author(s): Rudolf Lucas, Harald Hundsberger, Maren Pfluger, Bernhard Fischer, Denis Morel, Clemens Braun, Albrecht Wendel, Trinad Chakraborty, Wolfgang Schutt, Christoph Wiesner and Jurg Hamacher

Affiliation:

Keywords: TNF, Pulmonary edema, Sodium channels, Lectin, Peptide

Abstract: In view of the significant side-effects of existing substances as well as of supportive therapies for the treatment of pulmonary edema, there is a renewed search for novel drugs that increase the uptake of sodium in type II alveolar epithelial cells, a phenomenon which is crucial for lung liquid clearance. We describe here the discovery and characterization of a Tumor Necrosis Factor (TNF)-derived peptide mimicking the lectin-like domain of the cytokine as a potential novel anti-edema agent.

Cite this article as:

Lucas Rudolf, Hundsberger Harald, Pfluger Maren, Fischer Bernhard, Morel Denis, Braun Clemens, Wendel Albrecht, Chakraborty Trinad, Schutt Wolfgang, Wiesner Christoph and Hamacher Jurg, The Tumor Necrosis Factor-Derived TIP Peptide: A Potential Anti-Edema Drug, Letters in Drug Design & Discovery 2007; 4 (5) . https://dx.doi.org/10.2174/157018007780867816