Abstract
Senescence is an ageing process characterized by progressive and irreversible dysfunction of various physiological systems. Physiological senescence with advancing age is not a disease, but it affects the life-span and life-quality of elderly people. Brain functions such as cognition and motor skills, as with other organ systems, are impaired in almost all elderly people. Neuroprotective dietary components can play a key role in ensuring healthy ageing of the brain. Although the causative mechanisms of senescence are complex and not yet fully elucidated, enhanced oxidative stress is thought to be an important contributor. Dietary antioxidants from fruits and vegetables have preventative effects on oxidative stress. Catechin, a polyphenol found in green tea, has a potent antioxidative effect. Recently, catechin has been reported to protect against reduced ageing-related cognitive functions such as those associated with learning and memory, and ischemic brain damage. Catechin may act as a neuroprotective agent in progressive neurodegenerative disorders such as Parkinsons and Alzheimers diseases. The neuroprotective effects and putative mechanisms of action of catechin and other antioxidants are examined and discussed in this review.
Keywords: Antioxidant, brain, green tea catechin, learning, &, memory, oxidative damage, senescence
Central Nervous System Agents in Medicinal Chemistry
Title: Brain Senescence and Neuroprotective Dietary Components
Volume: 7 Issue: 2
Author(s): Keiko Unno*Minoru Hoshino
Affiliation:
- Laboratory of Bioorganic Chemistry, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka,Japan
Keywords: Antioxidant, brain, green tea catechin, learning, &, memory, oxidative damage, senescence
Abstract: Senescence is an ageing process characterized by progressive and irreversible dysfunction of various physiological systems. Physiological senescence with advancing age is not a disease, but it affects the life-span and life-quality of elderly people. Brain functions such as cognition and motor skills, as with other organ systems, are impaired in almost all elderly people. Neuroprotective dietary components can play a key role in ensuring healthy ageing of the brain. Although the causative mechanisms of senescence are complex and not yet fully elucidated, enhanced oxidative stress is thought to be an important contributor. Dietary antioxidants from fruits and vegetables have preventative effects on oxidative stress. Catechin, a polyphenol found in green tea, has a potent antioxidative effect. Recently, catechin has been reported to protect against reduced ageing-related cognitive functions such as those associated with learning and memory, and ischemic brain damage. Catechin may act as a neuroprotective agent in progressive neurodegenerative disorders such as Parkinsons and Alzheimers diseases. The neuroprotective effects and putative mechanisms of action of catechin and other antioxidants are examined and discussed in this review.
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Cite this article as:
Unno Keiko*, Hoshino Minoru, Brain Senescence and Neuroprotective Dietary Components, Central Nervous System Agents in Medicinal Chemistry 2007; 7 (2) . https://dx.doi.org/10.2174/187152407780831639
DOI https://dx.doi.org/10.2174/187152407780831639 |
Print ISSN 1871-5249 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6166 |
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