Abstract
Senescence is an ageing process characterized by progressive and irreversible dysfunction of various physiological systems. Physiological senescence with advancing age is not a disease, but it affects the life-span and life-quality of elderly people. Brain functions such as cognition and motor skills, as with other organ systems, are impaired in almost all elderly people. Neuroprotective dietary components can play a key role in ensuring healthy ageing of the brain. Although the causative mechanisms of senescence are complex and not yet fully elucidated, enhanced oxidative stress is thought to be an important contributor. Dietary antioxidants from fruits and vegetables have preventative effects on oxidative stress. Catechin, a polyphenol found in green tea, has a potent antioxidative effect. Recently, catechin has been reported to protect against reduced ageing-related cognitive functions such as those associated with learning and memory, and ischemic brain damage. Catechin may act as a neuroprotective agent in progressive neurodegenerative disorders such as Parkinsons and Alzheimers diseases. The neuroprotective effects and putative mechanisms of action of catechin and other antioxidants are examined and discussed in this review.
Keywords: Antioxidant, brain, green tea catechin, learning, &, memory, oxidative damage, senescence
Central Nervous System Agents in Medicinal Chemistry
Title: Brain Senescence and Neuroprotective Dietary Components
Volume: 7 Issue: 2
Author(s): Keiko Unno*Minoru Hoshino
Affiliation:
- Laboratory of Bioorganic Chemistry, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka,Japan
Keywords: Antioxidant, brain, green tea catechin, learning, &, memory, oxidative damage, senescence
Abstract: Senescence is an ageing process characterized by progressive and irreversible dysfunction of various physiological systems. Physiological senescence with advancing age is not a disease, but it affects the life-span and life-quality of elderly people. Brain functions such as cognition and motor skills, as with other organ systems, are impaired in almost all elderly people. Neuroprotective dietary components can play a key role in ensuring healthy ageing of the brain. Although the causative mechanisms of senescence are complex and not yet fully elucidated, enhanced oxidative stress is thought to be an important contributor. Dietary antioxidants from fruits and vegetables have preventative effects on oxidative stress. Catechin, a polyphenol found in green tea, has a potent antioxidative effect. Recently, catechin has been reported to protect against reduced ageing-related cognitive functions such as those associated with learning and memory, and ischemic brain damage. Catechin may act as a neuroprotective agent in progressive neurodegenerative disorders such as Parkinsons and Alzheimers diseases. The neuroprotective effects and putative mechanisms of action of catechin and other antioxidants are examined and discussed in this review.
Export Options
About this article
Cite this article as:
Unno Keiko*, Hoshino Minoru, Brain Senescence and Neuroprotective Dietary Components, Central Nervous System Agents in Medicinal Chemistry 2007; 7 (2) . https://dx.doi.org/10.2174/187152407780831639
DOI https://dx.doi.org/10.2174/187152407780831639 |
Print ISSN 1871-5249 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6166 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
The Antidepressant-like Effects of Estrogen-mediated Ghrelin
Current Neuropharmacology Recent Developments in Nanomedicines for Management of Various Health Issues Via Metabolism and Physico-Chemical Properties
Current Drug Metabolism Proteomics Approaches to Understand Linkage Between Alzheimer’s Disease and Type 2 Diabetes Mellitus
CNS & Neurological Disorders - Drug Targets The Many Faces of Glutathione Transferase Pi
Current Molecular Medicine The Two Faces of Iminoalditols: Powerful Inhibitors Trigger Glycosidase Activation
Current Enzyme Inhibition Comparative Evaluation of Ethanolic Extracts of Bacopa monnieri, Evolvulus alsinoides, Tinospora cordifolia and their Combinations on Cognitive Functions in Rats
Current Aging Science Antioxidant Treatment and Endothelial Dysfunction: Is it Time for Flavonoids?
Recent Patents on Cardiovascular Drug Discovery The Impact of Small Heat Shock Proteins (HspBs) in Alzheimer’s and Other Neurological Diseases
Current Pharmaceutical Design Modelling Human Disease with Pluripotent Stem Cells
Current Gene Therapy Review of Synthesis, Biological Assay and QSAR Studies of β-Secretase Inhibitors
Current Computer-Aided Drug Design NMDA Neurotransmission Dysfunction in Mild Cognitive Impairment and Alzheimers Disease
Current Pharmaceutical Design Ubiquitin-Protein Ligases - Novel Therapeutic Targets?
Current Protein & Peptide Science Impact of Cytokines and Chemokines on Alzheimer’s Disease Neuropathological Hallmarks
Current Alzheimer Research Erythropoietin Signaling and Neuroprotection
Current Signal Transduction Therapy Antiglycation Activity of Triazole Schiff’s Bases Against Fructosemediated Glycation: In Vitro and In Silico Study
Medicinal Chemistry Editorial (Mini Hot-Topic: Determination of the Antioxidant Capacity of Dietary Substances and Extracts from Natural Sources at Molecular, Cellular And Whole Tissue Level: Sensors and Complex Microfluidic Structures)
Current Analytical Chemistry Properties and Pathogenicity of Prion-Derived Peptides
Protein & Peptide Letters Old Friends in New Constellations - the Hematopoetic Growth Factors G-CSF, GMCSF, and EPO for the Treatment of Neurological Diseases
Current Medicinal Chemistry Preface: What is Aging for? That Remains the Question
Current Aging Science The Role of Adenosine in Alzheimers Disease
Current Neuropharmacology