The Role of Vitamin D in the Pathogenesis of NOD Mouse Diabetes

Author(s): Conny Gysemans , Brigitte Decallonne , Evelyne van Etten , Chantal Mathieu .

Journal Name: Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Under Re-organization)

Volume 7 , Issue 3 , 2007

Abstract:

The existence of β-cell dysfunction and insulin resistance in vitamin D-deficient individuals on top of the demonstrated presence of receptors for 1,25-dihydroxyvitamin D3, the active metabolite of vitamin D, in pancreatic islet β- cells and immune cells have lead to scientific and clinical interest in vitamin D with respect to its potential role in the pathogenesis of type 1 diabetes. Also, its therapeutic potential in the prevention of type 1 diabetes has been studied, especially since the availability of synthetic analogues of the molecule that lack its calcemic effects. Solid evidence is available on the detrimental effects of vitamin D deficiency on insulin synthesis and secretion in animal models as well as in humans. Interventions with pharmacological doses of 1,25-dihydroxyvitamin D3 are able to delay onset of autoimmune diabetes in NOD mice mainly through immune modulation.

Keywords: Vitamin D, 1,25(OH)2D3, type 1 diabetes, β-cell, NOD mouse, prevention, vitamin D deficiency, analogue

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Article Details

VOLUME: 7
ISSUE: 3
Year: 2007
Page: [203 - 209]
Pages: 7
DOI: 10.2174/187152207780832379
Price: $58