Nanoclay-Catalyzed Tandem Conjugate Addition-Annulation Protocol for Imidazo-1,3-Thiazines

Author(s): Lal Dhar Singh Yadav, Ritu Kapoor.

Journal Name: Letters in Organic Chemistry

Volume 4 , Issue 3 , 2007

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Abstract:

A nanoclay-catalyzed atom and energy-efficient low hazardous tandem conjugate additioncyclodehydration of cyclic thioureas (ethylenethiourea and 2-mercaptoimidazole/-benzimidazole) with dielectrophiles (chalcones) readily annulates a 1,3-thiazine ring on imidazoles to yield 7H-imidazo[2,1-b]-1,3- thiazines under solvent-free microwave irradiation in a one-pot procedure.

Keywords: Nanoclay-catalyzed, solvent-free, chalcones, cyclic thioureas, microwaves, imidazo-1,3-thiazines

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Article Details

VOLUME: 4
ISSUE: 3
Year: 2007
Page: [218 - 221]
Pages: 4
DOI: 10.2174/157017807780737228
Price: $58

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