Synthesis and Cytotoxic Activity of Steroidal Phosphorothioate,Phosphoroselenoate, and Phosphate Derivatives Conjugated with 3-Azido-3-Deoxythymidine

Author(s): Peiyuan Jin, Sanhao Ji, Yong Ju, Yufen Zhao.

Journal Name: Letters in Organic Chemistry

Volume 4 , Issue 3 , 2007

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Abstract:

Some steroidal phosphorothioate, phosphoroselenoate, and phosphate derivatives conjugated with 3-Azido-3-deoxythymidine (AZT) have been synthesized in good yields and their structures were confirmed on the basis of spectral methods. The result has shown that some of bioconjugates possess activity against breast cancer MCF-7 in bioassay.

Keywords: Steroidal conjugate, AZT, phosphate, cytotoxic activity

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Article Details

VOLUME: 4
ISSUE: 3
Year: 2007
Page: [189 - 192]
Pages: 4
DOI: 10.2174/157017807780737336
Price: $58

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