Synthesis of Asymmetric Peptide Mimetic Compounds Containing Tartaric Acid Core. Potential Inhibitors of HIV-1 Protease

Author(s): Gabriel O. de Resende, Lucia C. S. Aguiar, Bruno A. Cotrim, Joao F. C. da Silva, O. A. C.Antunes.

Journal Name: Letters in Organic Chemistry

Volume 4 , Issue 3 , 2007

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Abstract:

Dihydroxyethylene containing compounds, envisaged as aspartic protease inhibitors (cores), were easily synthesized in few steps, by a sequence involving ring opening of diacetyl tartaric anhydride, peptide coupling and de-esterification under basic conditions affording the desired diols in a simple and inexpensive method.

Keywords: HIV-Protease, inhibitor, dihydroxyethylene, diacetyl tartaric anhydride, ring opening, peptide, mimetic

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Article Details

VOLUME: 4
ISSUE: 3
Year: 2007
Page: [168 - 171]
Pages: 4
DOI: 10.2174/157017807780737200
Price: $58

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