Current Rheumatology Reviews

Dr. Serena Guiducci  
Department of Biomedicine, Division of Rheumatology
University of Florence


Pathophysiology and Treatment of Fibromyalgia Syndrome

Author(s): Thomas Stratz, Marion Schneider, Thomas O. Joos, Hsin-Yun Hsu, Wolfgang Muller.


Fibromyalgia syndrome is not a diagnosis in itself, but merely represents a set of classification criteria. It is possible to distinguish between different subgroups. Such a distinction can be made on the basis of psychopathological, clinical and laboratory tests. One subgroup reveals elevated level of different cytokines. The treatment of primary fibromyalgia can be optimized by taking these subgroups into consideration since one group responds better to 5-HT3 receptor antagonists, whereas another benefits more from antidepressants and a third group from psychotherapy. In socalled secondary fibromyalgia, 5-HT3 receptor antagonists may be used in the attempt to manage pain that might still persist after treatment of the primary disease.

Keywords: Fibromyalgia, subgroups, antidepressants, treatment, tropisetron, 5-HT3-receptor antagonists, psychotherapy

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Article Details

Year: 2007
Page: [167 - 170]
Pages: 4
DOI: 10.2174/157339707780619386
Price: $58