Current Bioinformatics

Yi-Ping Phoebe Chen
Department of Computer Science and Information Technology
La Trobe University
Melbourne
Australia

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Inference of Gene Regulatory Networks and its Validation

Author(s): Fang-Xiang Wu.

Abstract:

Genes encode proteins, some of which in turn regulate other genes. Such interactions make up a gene regulatory network. The understanding and unraveling of gene regulatory networks have been proven very useful in disease diagnosis and genomic drug design. Due to the complexity of gene regulatory networks, the completely understanding of their dynamics is difficult to achieve only through biological experiments without any computational aids. As a consequence, computational models for gene regulatory networks are indispensable. Recently a wide variety of different computational models have been proposed for inferring gene regulatory networks. This paper surveys some of computational models for inferring large gene regulatory networks, in particular, Boolean network model, differential/ difference equation models, and state-space models. Some advantages and disadvantages of these models are commented on. Some criteria for validating the inferred gene regulatory networks are also discussed from the bioinformatics perspective. Finally, several directions of the future work for modeling gene regulatory networks are proposed.

Keywords: Gene regulatory network, Boolean network model, differential/difference model, state-space model, gene expression data, validation

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Article Details

VOLUME: 2
ISSUE: 2
Year: 2007
Page: [139 - 144]
Pages: 6
DOI: 10.2174/157489307780618240
Price: $58