Effect of Fluoxetine on Brain Oxidative Stress, Neuronal Damage and Behavioural Induced in the Olfactory Bulbectomy Model of Depression

Author(s): Isaac Tunez, Francisco J. Medina, Ignacio Jimena, María del C. Munoz.

Journal Name: Letters in Drug Design & Discovery

Volume 4 , Issue 4 , 2007

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Abstract:

We demonstrate that olfactory bulbectomy produced oxidative and cell damage together with behavioural changes. This situation was reversed by fluoxetine administration. The data suggest that oxidative stress may represent common pathophysiological mechanisms in this experimental model, as well as that beneficial effect of fluoxetine may be mediated by antioxidative action.

Keywords: Lipid Peroxidation, caspase-3, GSH-peroxidase, selective serotonin reuptake inhibitors, Open Field Test

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Article Details

VOLUME: 4
ISSUE: 4
Year: 2007
Page: [305 - 310]
Pages: 6
DOI: 10.2174/157018007784620013
Price: $58

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