In vitro Antimicrobial Activity of Liposomes Containing Ciprofloxacin,Meropenem and Gentamicin Against Gram-Negative Clinical Bacterial Strains

Title: In vitro Antimicrobial Activity of Liposomes Containing Ciprofloxacin,Meropenem and Gentamicin Against Gram-Negative Clinical Bacterial Strains

Volume: 4 Issue: 4

Author(s): Jerzy Gubernator, Zuzanna Drulis-Kawa, Agata Dorotkiewicz-Jach, Wlodzimierz Doroszkiewicz and Arkadiusz Kozubek

Affiliation:

Keywords: Liposomes, Meropenem, Gentamicin, Ciprofloxacin, Bacteria

Abstract: The antimicrobial activity of two cationic liposomes containing three antibiotics were tested in vitro. Ciprofloxacin loaded in liposomes exhibited a 2-4 times higher antimicrobial activity compared with the free drug. The bacterial sensitivity to liposomal meropenem were similar as to free antibiotic. The least effective were the liposomes containing gentamicin.

Cite this article as:

Gubernator Jerzy, Drulis-Kawa Zuzanna, Dorotkiewicz-Jach Agata, Doroszkiewicz Wlodzimierz and Kozubek Arkadiusz, In vitro Antimicrobial Activity of Liposomes Containing Ciprofloxacin,Meropenem and Gentamicin Against Gram-Negative Clinical Bacterial Strains, Letters in Drug Design & Discovery 2007; 4 (4) . https://dx.doi.org/10.2174/157018007784620040