Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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In vitro Antimicrobial Activity of Liposomes Containing Ciprofloxacin,Meropenem and Gentamicin Against Gram-Negative Clinical Bacterial Strains

Author(s): Jerzy Gubernator, Zuzanna Drulis-Kawa, Agata Dorotkiewicz-Jach, Wlodzimierz Doroszkiewicz, Arkadiusz Kozubek.

Abstract:

The antimicrobial activity of two cationic liposomes containing three antibiotics were tested in vitro. Ciprofloxacin loaded in liposomes exhibited a 2-4 times higher antimicrobial activity compared with the free drug. The bacterial sensitivity to liposomal meropenem were similar as to free antibiotic. The least effective were the liposomes containing gentamicin.

Keywords: Liposomes, Meropenem, Gentamicin, Ciprofloxacin, Bacteria

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Article Details

VOLUME: 4
ISSUE: 4
Year: 2007
Page: [297 - 304]
Pages: 8
DOI: 10.2174/157018007784620040
Price: $58