Copper Complexes of Henna-Sulforaphane Conjugates as Potent Antiproliferative Agents Against Human Myeloma KBM-5 Cells Through Blockade of Transcription Factor NF-κB
B. B. Aggarwal.
The semi-thiosemicarbazone and N4-substituted thiosemicarbazone derivatives and their metal complexes of the active principle of Henna were structurally characterized along with single crystal X-ray studies. The compounds were evaluated for their antiproliferative activity against human leukemia KBM-5 cells, where [Cu(3)] was the most active compound with IC50 of 0.3 μM attributed to down regulation of NF-κB activation.
Keywords: Human myeloid leukemia, Copper complexes, Naphthoquinones, Sulforaphanes, NF-κB inhibition, Henna derivatives
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