Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Copper Complexes of Henna-Sulforaphane Conjugates as Potent Antiproliferative Agents Against Human Myeloma KBM-5 Cells Through Blockade of Transcription Factor NF-κB

Author(s): K. Shirisha, J. Patole, S. Padhye, E. Sinn, S. Shishodia, B. B. Aggarwal.

Abstract:

The semi-thiosemicarbazone and N4-substituted thiosemicarbazone derivatives and their metal complexes of the active principle of Henna were structurally characterized along with single crystal X-ray studies. The compounds were evaluated for their antiproliferative activity against human leukemia KBM-5 cells, where [Cu(3)] was the most active compound with IC50 of 0.3 μM attributed to down regulation of NF-κB activation.

Keywords: Human myeloid leukemia, Copper complexes, Naphthoquinones, Sulforaphanes, NF-κB inhibition, Henna derivatives

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Article Details

VOLUME: 4
ISSUE: 4
Year: 2007
Page: [257 - 262]
Pages: 6
DOI: 10.2174/157018007784620059
Price: $58