Synthesis and Evaluation of 2-Substituted Fendiline Analogues as Antileukemics

Author(s): James A. Wilkinson , Steven B. Rossington , Nicholas A. Coe , Nicholas Hirst , Alan T. McGown , John Leonard , Nigel Hussain .

Journal Name: Letters in Drug Design & Discovery

Volume 4 , Issue 4 , 2007

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Abstract:

A series of novel, 2-substituted derivatives of fendiline have been synthesised and their ability to inhibit growth of human leukaemia cells (K562) determined. Of these derivatives, the 2-hydroxy compounds 26 and 27 had a significantly greater inhibitory effect on K562 cells than fendiline.

Keywords: Fendiline, Antileukemic compounds, Diphenylmethanes

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Article Details

VOLUME: 4
ISSUE: 4
Year: 2007
Page: [246 - 248]
Pages: 3
DOI: 10.2174/157018007784620068
Price: $58

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