Synthesis and Evaluation of 2-Substituted Fendiline Analogues as Antileukemics
James A. Wilkinson,
Steven B. Rossington,
Nicholas A. Coe,
Alan T. McGown,
A series of novel, 2-substituted derivatives of fendiline have been synthesised and their ability to inhibit growth of human leukaemia cells (K562) determined. Of these derivatives, the 2-hydroxy compounds 26 and 27 had a significantly greater inhibitory effect on K562 cells than fendiline.
Keywords: Fendiline, Antileukemic compounds, Diphenylmethanes
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