Current Pediatric Reviews

Giuseppe Buonocore
Department of Molecular and Developmental Medicine
University of Siena
Siena
Italy

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Renal Tubular Acidosis

Author(s): Iradj Amirlak, Hassib Narchi, Lihadh Al-Gazali.

Abstract:

Renal tubular acidosis (RTA), a clinical syndrome with hyperchloremic metabolic acidosis with normal anion gap, is an uncommon and sometimes overlooked condition. It may have multiple causes, some sporadic, some genetically transmitted; some are isolated or may be associated with other renal or systemic pathologies or diseases. All these factors add to the complexity of recognition and management of this extended range of conditions. We hereby describe several children with different types of RTA, illustrating the different mode of presentations and some of the etiologies. Pathophysiology is reviewed, as well as the practical approach to the diagnosis and management. In addition, recent genetically identified conditions are reviewed, with emphasis on increasingly recognized association with other systems involvement.

Keywords: Acidosis, renal tubular, complications, diagnosis, etiology

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Article Details

VOLUME: 3
ISSUE: 2
Year: 2007
Page: [103 - 107]
Pages: 5
DOI: 10.2174/157339607780599038
Price: $58