Rapid Syntheses of Biologically Active Quinazolinone Natural Products Using Microwave Technology

Author(s): Ji-Feng Liu.

Journal Name: Current Organic Synthesis

Volume 4 , Issue 2 , 2007

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Quinazolinone alkaloids are a class of natural products possessing a variety of biological activities. In addition, the quinazolinone core scaffold has been extensively utilized as a drug-like template in medicinal chemistry and considered a privileged structure. We have devised a novel, one-pot, highly efficient entry into multiply substituted quinazolinones using microwave technology and applied this methodology to the total syntheses of series of quinazolinone-containing natural products. This review will highlight the total syntheses of these natural products and their analogs under microwave conditions.

Keywords: Natural Products, Microwave Irradiation, Alantrypinone, quinazolinobenzodiazepine alkaloid, asperlicin E, isaindigotone

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Article Details

Year: 2007
Page: [223 - 237]
Pages: 15
DOI: 10.2174/157017907780598871
Price: $58

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