Abstract
This review covers different synthetic routes to the C-13 side-chain of taxol the most potent antimicrotubule agent first isolated from Texus bravifolia and later on from several other species of Taxus. The different approaches reported for the syntheses of the C-13 side-chain of taxol are catagorized on the synthetic strategies applied.
Keywords: Taxol, 10-DAB, C-13 side-chain, total synthesis, antimicotubule
Call for Papers in Thematic Issues
Exploring the Role of Chemical Graph Theory in Advancing Current Organic Synthesis
Organic synthesis is a fundamental discipline in chemistry, crucial for the creation of complex molecules with diverse applications in pharmaceuticals, materials science, and beyond. However, the process of designing efficient synthetic routes for target molecules remains challenging. Chemical graph theory, a branch of theoretical chemistry, offers powerful tools for understanding ...read more
Photoswitches for Molecular Recognition
This Special Issue would cover the hot topics on synthesis and chemical and photophysical characterization of new photoswitchable derivatives and their applications on molecular recognition of metabolites and biological active compounds, both in physiological medium and in living cells. Photoswitches are compounds that can change their conformation or properties in ...read more
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