Scaffold Assembly of Collagen-Like Triple Helices at the C-Terminus

Author(s): Weibo Cai, Joseph P. Taulane, Nohemy A. Sorto, Asmik Oganesyan, Carlos G. Gutierrez, Murray Goodman.

Journal Name: Letters in Organic Chemistry

Volume 4 , Issue 2 , 2007

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Here, we report the C-terminal scaffold assembly of triple helical collagen mimetics using a triserine lactone (TSL) scaffold. It was found that the TSL scaffold can promote the triple helix formation and enhance the thermal stability of the resulting collagen-like structures.

Keywords: Scaffold-assembled collagen mimetics, Triserine lactone, Triple helix, Collagen, Circular dichroism, Thermal denaturation

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Article Details

Year: 2007
Page: [96 - 101]
Pages: 6
DOI: 10.2174/157017807780414163
Price: $65

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