Chiral Pyrrolidine-Based Salen Ligands for the Enantioselective Alkylation of Aromatic Aldehydes

Title: Chiral Pyrrolidine-Based Salen Ligands for the Enantioselective Alkylation of Aromatic Aldehydes

Volume: 4 Issue: 2

Author(s): M. Elisa da Silva Serra, Dina Murtinho, Albertino Goth and A. M. d'A. Rocha Gonsalves

Affiliation:

Keywords: Pyrrolidine, diamine, Salen, diethylzinc, enantioselective, alkylation

Abstract: A new type of Salen ligands derived from (2R, 3R)-N-benzyl-2,3-diaminopyrrolidine and aromatic hydroxyaldehydes was synthesized and tested in the enantioselective alkylation of aromatic aldehydes with diethylzinc, moderate selectivity being observed. This study represents the application of a new type of Zn- Salen ligands and opens the way to exploring these promising new structures in other enantioselective and biological processes.

Cite this article as:

M. Elisa da Silva Serra , Murtinho Dina, Goth Albertino and d'A. Rocha Gonsalves M. A., Chiral Pyrrolidine-Based Salen Ligands for the Enantioselective Alkylation of Aromatic Aldehydes, Letters in Organic Chemistry 2007; 4 (2) . https://dx.doi.org/10.2174/157017807780414118