Characterization of a Novel ADPase in Bothrops jararaca Snake Venom Involved in Nucleotide Hydrolysis

Author(s): Andre Teixeira-Ferreira, Elias Walter Alves.

Journal Name: Protein & Peptide Letters

Volume 14 , Issue 4 , 2007

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Abstract:

Snake venoms hydrolyze several phosphorylated substrates. However, not is clearly understood which enzyme( s) is (are) involved in these process. Here, we propose the existence of an independent ADPase activity. In addition, we studied the reactions mechanism of nucleotide hydrolysis. This system resembles membrane ecto-nucleotidases and acts with a multi enzymatic complex transforming ATP in adenosine without the accumulation of intermediates.

Keywords: Bothrops jararaca, ATP-pyrophosphatase, ATPase, ADPase, Phosphodiesterase, 5'-nucleotidase

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Article Details

VOLUME: 14
ISSUE: 4
Year: 2007
Page: [395 - 402]
Pages: 8
DOI: 10.2174/092986607780363998
Price: $58

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