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Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Discontinued)

Editor-in-Chief

ISSN (Print): 1871-5222
ISSN (Online): 1875-6115

Adipobiology of Diabetes Mellitus

Author(s): M. J. Kim, E. Y. Lee, M. Y. Lee and C. H. Chung

Volume 7, Issue 2, 2007

Page: [123 - 127] Pages: 5

DOI: 10.2174/187152207780363776

Price: $65

Abstract

Accumulating basic and clinical studies indicate that adipose tissue cells (adipocytes, matrix cells, stromovascular cells and associated macrophages) synthesize and release multiple signaling proteins collectively termed adipokines. Adipokines regulate a broad spectrum of biological processes, with glucose and lipid metabolism being a key example. This defines a new field of study: adipobiology of type 2 diabetes mellitus. The importance of diabetes-related (diabetogenic) adipokines, with an emphasis on adiponectin, resistin, leptin, angiotensin II, tumor necrosis factor-α , interleukin-6, and visfatin, is reviewed. Competing of pro- and anti-diabetogenic adipokine-mediated signals may pivotally be involved in the adipobiology of diabetes. This paradigm may reveal further new tools for drug development against diabetes and related disorders.

Keywords: Adiponectin, angiotensin II, drugs, IL-6, leptin, resistin, TNF-α, visfatin


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