Adipobiology of Diabetes Mellitus

Author(s): M. J. Kim, E. Y. Lee, M. Y. Lee, C. H. Chung.

Journal Name: Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Under Re-organization)

Volume 7 , Issue 2 , 2007

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Abstract:

Accumulating basic and clinical studies indicate that adipose tissue cells (adipocytes, matrix cells, stromovascular cells and associated macrophages) synthesize and release multiple signaling proteins collectively termed adipokines. Adipokines regulate a broad spectrum of biological processes, with glucose and lipid metabolism being a key example. This defines a new field of study: adipobiology of type 2 diabetes mellitus. The importance of diabetes-related (diabetogenic) adipokines, with an emphasis on adiponectin, resistin, leptin, angiotensin II, tumor necrosis factor-α , interleukin-6, and visfatin, is reviewed. Competing of pro- and anti-diabetogenic adipokine-mediated signals may pivotally be involved in the adipobiology of diabetes. This paradigm may reveal further new tools for drug development against diabetes and related disorders.

Keywords: Adiponectin, angiotensin II, drugs, IL-6, leptin, resistin, TNF-α, visfatin

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Article Details

VOLUME: 7
ISSUE: 2
Year: 2007
Page: [123 - 127]
Pages: 5
DOI: 10.2174/187152207780363776
Price: $58