Radiolabeled Peptides and Proteins in Cancer Therapy

Author(s): Carmen Wangler, Inga Buchmann, Michael Eisenhut, Uwe Haberkorn, Walter Mier.

Journal Name: Protein & Peptide Letters

Volume 14 , Issue 3 , 2007

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Abstract:

With the advances in genomics, molecular biology including gene vector technologies todays molecular imaging modalities have strongly been improved. The major progress is based on peptide and antibody targeting vectors. When labeled with β-emitting radioisotopes these agents are applicable for endoradiotherapy and exploit the targeting potential for highly specific therapeutic applications. This novel class of pharmaceuticals offers the potential to develop patient specific therapies and might provide the means to go beyond the possibilities of current chemotherapy and radiation therapy. In this review the basic principles of endoradiotherapeutics based on peptides and proteins are presented. Several of these drugs such as 90Y-rituximab (Zevalin), 131I-tositumomab (Bexxar) and the somatostatin receptor binding 90YDOTATOC that are nowadays successfully applied in oncological therapy are discussed. Future generations of endoradiopharmaceuticals will address yet unknown targets which might be identified by screening techniques such as ribosome and phage display peptide libraries.

Keywords: Endoradiotherapy, oncology, labeling, radioisotopes, targeting

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Article Details

VOLUME: 14
ISSUE: 3
Year: 2007
Page: [273 - 279]
Pages: 7
DOI: 10.2174/092986607780090874
Price: $58

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