Synthesis and Antitumor Activity of Novel Pentacyclic Triterpenoid Lantadene D
Pritam Dev Sharma,
Mohinder Pal Bansal,
Lantadene D was semi-synthetically prepared by functionalizing 22β-hydroxyoleanonic acid and screened for cytotoxicity against four human cancer cell lines (HL-60, HeLa, Colon 502713 and Lung A-549). It was further evaluated for its inhibitory profile against two-stage carcinogenesis in Swiss albino mice.
Keywords: Lantadene D, Cytotoxicity, Antitumor, 12-O- Tetradecanoylphorbol-13 acetate (TPA), 7, 12-Dimethylbenz [a] anthracene (DMBA)
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