Search for Potential Non-Steroidal Inhibitors of 17 β-Hydroxysteroid Dehydrogenase (17 β-HSD) in the Treatment of Hormone-Dependent Cancers

Title: Search for Potential Non-Steroidal Inhibitors of 17 β-Hydroxysteroid Dehydrogenase (17 β-HSD) in the Treatment of Hormone-Dependent Cancers

Volume: 4 Issue: 3

Author(s): Rupinder K. Lota, Sachin Dhanani, Caroline P. Owen and Sabbir Ahmed

Affiliation:

Keywords: 17β-hydroxysteroid dehydrogenase, Type 3, Inhibition, Enzyme inhibition, Biphenyl ketones

Abstract: We report the search for non-steroidal inhibitors of 17β-hydroxysteroid dehydrogenase, in particular, for types 1 and 3. The results show that the synthesised compounds based on the biphenyl backbone were good inhibitors of 17β-HSD1, but were weak inhibitors of 17β-HSD3. The compounds were evaluated against 3β-HSD but showed weak inhibition.

Cite this article as:

Lota K. Rupinder, Dhanani Sachin, Owen P. Caroline and Ahmed Sabbir, Search for Potential Non-Steroidal Inhibitors of 17 β-Hydroxysteroid Dehydrogenase (17 β-HSD) in the Treatment of Hormone-Dependent Cancers, Letters in Drug Design & Discovery 2007; 4 (3) . https://dx.doi.org/10.2174/157018007780077417