Increase in Pharmacological Activity of Drugs in their Clathrates with Plant Glycosides

Author(s): T. G. Tolstikova, A. O. Bryzgalov, I. V. Sorokina, M. V. Hvostov, A. S. Ratushnyak, T. A. Zapara, O. G. Simonova.

Journal Name: Letters in Drug Design & Discovery

Volume 4 , Issue 3 , 2007

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Abstract:

The effect of pharmacones clathration with glycosides results in significant decrease of drug agent dosage. We investigated the clathrates of hypotensive agent Nifedipine with glycyrrhizic acid, which was prepared in molecular proportion 1:4 respectively. Present study was carried out on the calcium channels on neurons of Lymnaea stagnalis mollusc.

Keywords: Pharmacones clathration, Nifedipine, Glycyrrhizic acid, Calcium channels

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Article Details

VOLUME: 4
ISSUE: 3
Year: 2007
Page: [168 - 170]
Pages: 3
DOI: 10.2174/157018007780077453
Price: $58