Increase in Pharmacological Activity of Drugs in their Clathrates with Plant Glycosides
T. G. Tolstikova,
A. O. Bryzgalov,
I. V. Sorokina,
M. V. Hvostov,
A. S. Ratushnyak,
T. A. Zapara,
O. G. Simonova.
The effect of pharmacones clathration with glycosides results in significant decrease of drug agent dosage. We investigated the clathrates of hypotensive agent Nifedipine with glycyrrhizic acid, which was prepared in molecular proportion 1:4 respectively. Present study was carried out on the calcium channels on neurons of Lymnaea stagnalis mollusc.
Keywords: Pharmacones clathration, Nifedipine, Glycyrrhizic acid, Calcium channels
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