FtsZ: A Novel Target for Tuberculosis Drug Discovery

Author(s): Qing Huang, Peter J. Tonge, Richard A. Slayden, Teruo Kirikae, Iwao Ojima.

Journal Name: Current Topics in Medicinal Chemistry

Volume 7 , Issue 5 , 2007

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Abstract:

The emergence of multi-drug resistant Mycobacterium tuberculosis (Mtb) strains has made many of the currently available anti-TB drugs ineffective. Accordingly there is a pressing need to identify new drug targets. FtsZ, a bacterial tubulin homologue, is an essential cell division protein that polymerizes in a GTP-dependent manner, forming a highly dynamic cytokinetic ring, designated as the Z ring, at the septum site. Following recruitment of other cell division proteins, the Z ring contracts, resulting in closure of the septum and then formation of two daughter cells. Since inactivation of FtsZ or alteration of FtsZ assembly results in the inhibition of Z ring and septum formation, FtsZ is a very promising target for new antimicrobial drug development. This review describes the function and dynamic behaviors of FtsZ, its homology to tubulin, and recent development of FtsZ inhibitors as potential anti-TB agents.

Keywords: FtsZ, tubulin, GTPase, homology, GTP hydrolysis, polymerization, dynamics, inhibitor

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Article Details

VOLUME: 7
ISSUE: 5
Year: 2007
Page: [527 - 543]
Pages: 17
DOI: 10.2174/156802607780059790
Price: $58

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