Nucleophilic Substitution Reactions in Ionic Liquid: Towards a Real Continuous-Flow Process for Synthesis of Alkyl Bromides and Cyanides

Author(s): Zhiming Wang, Zhe Li, Weiliang Bao.

Journal Name: Letters in Organic Chemistry

Volume 4 , Issue 1 , 2007

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A real continuous-flow process for synthesis of alkyl bromides or cyanides was demonstrated by nucleophilic substitution reactions of tosylates with bromide and/or cyanide conducted in ionic liquid 1- ethyl-3-methylimidazolium tosylate. The process provides higher yields and shorter reaction time and is easily upgraded to large scale.

Keywords: Continuous-flow process, ionic liquid, nucleophilic substitution reaction, distillation, alkyl bromide, alkyl cyanide

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Article Details

Year: 2007
Page: [72 - 74]
Pages: 3
DOI: 10.2174/157017807780037333

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