Ionic Liquid/Silica Sulfuric Acid Promoted Fast Synthesis of a Biginelli-Like Scaffold Reaction

Author(s): Ahmad Shaabani , Afshin Sarvary , Abbas Rahmati , Ali Hossein Rezayan .

Journal Name: Letters in Organic Chemistry

Volume 4 , Issue 1 , 2007

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Biginelli-like scaffolds were synthesized in good yields by a three-component condensation reaction of 5,5-dimethyl-1,3-cyclohexanedione, an aldehyde and urea, N-methylurea or thiourea in 1-butyl-3- methylimidazolium bromide ([bmim]Br) as ionic liquid (IL) in the presence of silica sulfuric acid (SSA) as solid acid catalyst at 100 °C within less than 2 hours.

Keywords: Ionic liquid, silica sulfuric acid, Biginelli-like, [bmim]Br, catalyst, multi-component reaction

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Article Details

Year: 2007
Page: [68 - 71]
Pages: 4
DOI: 10.2174/157017807780037531

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