Aza-Michael Addition of Amines to Activated Alkenes Catalyzed by Silica Supported Perchloric Acid Under a Solvent-Free Condition

Author(s): Chinmoy Mukherjee, Anup Kumar Misra.

Journal Name: Letters in Organic Chemistry

Volume 4 , Issue 1 , 2007

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Abstract:

An efficient aza-Michael addition of amines to a series of α,β-unsaturated ketones, carboxylic esters, nitriles and chalcones has been carried out using perchloric acid supported over silica gel (HClO4-SiO2) at room temperature in high yields under solvent-free reaction conditions.

Keywords: Aza-Michael addition, amines, synthetic methods, electron-deficient alkenes, HClO4-SiO2, solvent-free

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Article Details

VOLUME: 4
ISSUE: 1
Year: 2007
Page: [54 - 59]
Pages: 6
DOI: 10.2174/157017807780037414

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