Multicomponent Solvent-Free Cyclocondensation/Glycosylation Strategy for Thiazolo-s-triazine N-Nucleosides

Author(s): Lal Dhar Singh Yadav, Vijai Kumar Rai, Seema Yadav.

Journal Name: Letters in Organic Chemistry

Volume 4 , Issue 1 , 2007

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Abstract:

A green protocol involving novel three-component one-pot cyclocondensation reactions of 2- amino-4-aryl-thiazoles, aromatic aldehydes and ammonium thiocyanate under solvent-free microwave irradiation (MWI) conditions expeditiously yields thiazolo-s-triazine nucleobases, which afford the corresponding pyrano N-nucleosides on I2 promoted glycosylation with 1,2,3,4-tetra-O-acetyl- β-D-ribo- /xylopyranose under MWI followed by deacetylation.

Keywords: Multicomponent reactions, solvent-free, glycosylation, microwaves, thiazolo-s-triazines, pyrano N-nucleosides

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Article Details

VOLUME: 4
ISSUE: 1
Year: 2007
Page: [47 - 50]
Pages: 4
DOI: 10.2174/157017807780037469

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