Multicomponent Synthesis of 3,4-Dihydropyrimidin-2-(1H)-Ones with a Cu/Silica Xerogel Composite Catalyst

Author(s): Dennis Russowsky, Edilson V. Benvenutti, Gabriela S. Roxo, Fabio Grasel.

Journal Name: Letters in Organic Chemistry

Volume 4 , Issue 1 , 2007

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The efficient multicomponent synthesis of 3,4-dihydropyrimidin-2(1H)-ones promoted by a heterogeneous Cu/silica xerogel composite is presented herein. This composite was synthesized by the sol-gel methodology employing CuCl2 as the metal source. The catalyst can be easily recovered and reused in subsequent reactions.

Keywords: Biginelli reaction, dihydropyrimidinones, sol-gel, metal/silica composites, catalysis

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Article Details

Year: 2007
Page: [39 - 42]
Pages: 4
DOI: 10.2174/157017807780037496

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