The efficient multicomponent synthesis of 3,4-dihydropyrimidin-2(1H)-ones promoted by a heterogeneous Cu/silica xerogel composite is presented herein. This composite was synthesized by the sol-gel methodology employing CuCl2 as the metal source. The catalyst can be easily recovered and reused in subsequent reactions.
Keywords: Biginelli reaction, dihydropyrimidinones, sol-gel, metal/silica composites, catalysis
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