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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Direct Synthesis of Weinreb Amides from Carboxylic Acids Using Triphosgene

Author(s): Ki-Jong Han and Misoo Kim

Volume 4, Issue 1, 2007

Page: [20 - 22] Pages: 3

DOI: 10.2174/157017807780037441

Price: $65

Abstract

Weinreb amides were conveniently prepared in high yields by reaction of carboxylic acids with N,Odimethylhydroxylamine hydrochloride at room temperature using triphosgene as an acid activator in the presence of triethylamine.

Keywords: Weinreb amides, triphosgene, carboxylic acids, N, O-dimethylhydroxylamine hydrochloride


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