Direct Synthesis of Weinreb Amides from Carboxylic Acids Using Triphosgene

Author(s): Ki-Jong Han, Misoo Kim.

Journal Name: Letters in Organic Chemistry

Volume 4 , Issue 1 , 2007

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Abstract:

Weinreb amides were conveniently prepared in high yields by reaction of carboxylic acids with N,Odimethylhydroxylamine hydrochloride at room temperature using triphosgene as an acid activator in the presence of triethylamine.

Keywords: Weinreb amides, triphosgene, carboxylic acids, N, O-dimethylhydroxylamine hydrochloride

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Article Details

VOLUME: 4
ISSUE: 1
Year: 2007
Page: [20 - 22]
Pages: 3
DOI: 10.2174/157017807780037441

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