Enantioselective Synthesis of 2,3-Disubstituted Piperidines

Author(s): Michael Calosso, Mathieu Wagner, Thomas Gendrineau, Morgane Petit, Catherine Kadouri-Puchot, Luc Dechoux.

Journal Name: Letters in Organic Chemistry

Volume 4 , Issue 1 , 2007

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Abstract:

Chiral derivative 3 has been recognized as a precursor of enantiopure 2,3-disubstituted piperidines. A study concerning the chemoselective reduction, using BH3.Me2S, of highly functionalised compounds 6 and N-BOC aminoacid 12 is reported.

Keywords: Asymmetric synthesis, pipecolic acids, piperidines, phenylglycinol, aza-annelation

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Article Details

VOLUME: 4
ISSUE: 1
Year: 2007
Page: [4 - 6]
Pages: 3
DOI: 10.2174/157017807780037487

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