Abstract
New prostaglandins analogues, containing heteroatoms in the cyclopentane ring were synthesized. The key step in the synthesis was the preparation of the five-membered ring starting from L-cysteine ethyl ester hydrochloride. The addition of the alkyl groups at C-15 position was also performed.
Keywords: Heterocyclic prostaglandins, azaprostaglandins, thiaprostaglandins
Letters in Organic Chemistry
Title: Synthesis of Novel Heterocyclic Prostaglandin Analogues
Volume: 4 Issue: 1
Author(s): Francisco C. Biaggio, Alessandra R. Rufino and Marcela C.F. Silveira
Affiliation:
Keywords: Heterocyclic prostaglandins, azaprostaglandins, thiaprostaglandins
Abstract: New prostaglandins analogues, containing heteroatoms in the cyclopentane ring were synthesized. The key step in the synthesis was the preparation of the five-membered ring starting from L-cysteine ethyl ester hydrochloride. The addition of the alkyl groups at C-15 position was also performed.
Export Options
About this article
Cite this article as:
Biaggio C. Francisco, Rufino R. Alessandra and Silveira C.F. Marcela, Synthesis of Novel Heterocyclic Prostaglandin Analogues, Letters in Organic Chemistry 2007; 4 (1) . https://dx.doi.org/10.2174/157017807780037388
DOI https://dx.doi.org/10.2174/157017807780037388 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Drugs and Foods for Chronic Subclinical Inflammation in Humans
Current Medicinal Chemistry - Immunology, Endocrine & Metabolic Agents Current Targets for Primary Sclerosing Cholangitis
Current Drug Targets Pharmacological Inhibition of Platelet Reactivity. Clinical and Pharmacodynamic Effects
Current Vascular Pharmacology Vascular Endothelial Growth Factor (VEGF) Signaling in Tumour Vascularization: Potential and Challenges
Current Vascular Pharmacology Multi-Component Reactions of Cyclohexan-1,3-dione: Synthesis of Fused Pyran, Pyridine, Thiophene and Pyrazole Derivatives with c-Met, Anti-Proliferative Activities
Anti-Cancer Agents in Medicinal Chemistry Inhibitory Effect of Codeine on Sucrase Activity
Drug Metabolism Letters Treatment Strategies for Multiple Myeloma in the Age of Novel Therapies
Current Cancer Therapy Reviews Terpenoids: Sources, Structure Elucidation and Therapeutic Potential in Inflammation
Current Topics in Medicinal Chemistry Dietary Omega 3 Polyunsaturated Fatty Acids and Alzheimers Disease: Interaction with Apolipoprotein E Genotype
Current Alzheimer Research Expiratory High-Resolution CT in Diffuse Lung Diseases
Current Respiratory Medicine Reviews Advanced Glycation End Products (AGEs) and their Involvement in Liver Disease
Current Pharmaceutical Design Genetic Approaches for Antigen-Selective Cell Therapy
Current Gene Therapy Biomarkers Downstream of RAS: A Search for Robust Transcriptional Targets
Current Cancer Drug Targets The Endothelium and Platelets in Cardiovascular Disease: Potential Targets for Therapeutic Intervention
Current Medicinal Chemistry - Cardiovascular & Hematological Agents Achievements and Bottlenecks of PEGylation in Nano-delivery Systems
Current Medicinal Chemistry Mechanism of Cardiac Pathogenesis and Cardiotoxicity of Anti- COVID-19 Drugs
Coronaviruses The Vascular Endothelin System in Hypertension - Recent Patents and Discoveries
Recent Patents on Cardiovascular Drug Discovery The Role of Androgen Under Normal and Pathological Conditions in Sebaceous Glands: The Possibility of Target Therapy
Current Molecular Pharmacology AMI and Anabolic-Androgenic Steroids: Case Report with Systematic Review
Current Cardiology Reviews A Balanced View of Efficacy and Safety of Aspirin in Cardiovascular Diseases
Current Pharmaceutical Design