Current Respiratory Medicine Reviews

Joseph Varon  
The University of Texas Health Science Center
Houston, TX


The Pathophysiology of Sleep Apnoea: What We have Learned from Animal Models of Chronic Intermittent Hypoxia

Author(s): Ken D. O'Halloran, Aidan Bradford.


Sleep apnoea is a common condition associated with significant morbidity and mortality. The English bulldog is the only animal known to have sleep apnoea. In recent years, a number of animal models have been developed which have contributed greatly to our knowledge of the condition. These models develop a number of pathophysiological changes similar to human sleep apnoea such as systemic and pulmonary hypertension, increased haematocrit, and effects on blood coaguability, cardiac rhythmogenesis and central nervous system and upper airway muscle function. This review will describe what has been learned from these models concerning the pathophysiology of sleep apnoea with special emphasis on the role played by intermittent hypoxia.

Keywords: Sleep apnoea, intermittent hypoxia, animal models, systemic hypertension, pulmonary hypertension, upper airway muscle

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Article Details

Year: 2007
Page: [19 - 27]
Pages: 9
DOI: 10.2174/157339807779941802