Oxazolidin-2-one Ring, a Popular Framework in Synthetic Organic Chemistry: Part 1. The Construction of the Oxazolidin-2-one Ring

Author(s): G. Zappia, E. Gacs-Baitz, G. Delle Monache, D. Misiti, L. Nevola, B. Botta.

Journal Name: Current Organic Synthesis

Volume 4 , Issue 1 , 2007

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Abstract:

The 1,3-oxazolidin-2-one nucleus is a popular heterocycle framework in synthetic organic chemistry, as well as in medicinal chemistry. This paper deals with the huge number of synthetic approaches addressed to the construction of this five-member ring, with a particular care for the mechanistic and stereochemical outcome.

Keywords: 1,3-Oxazolidin-2-one, cyclocarbamation reactions, 1,2-aminoalcohol, epoxides and aziridines, amino-acids, Curtius- rearrangement

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Article Details

VOLUME: 4
ISSUE: 1
Year: 2007
Page: [81 - 135]
Pages: 55
DOI: 10.2174/157017907779981552

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