Synthesis of Scaffolds with Glycomimetic Structures

Author(s): C. Gravier-Pelletier, Y. Le Merrer.

Journal Name: Current Organic Synthesis

Volume 4 , Issue 1 , 2007

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Efficient and total synthesis of enantiopure cyclitols with a C6, C7 or C8 ring as framework and related aminocyclitols, including polyhydroxylated octahydroindoles and decahydroquinolines are reported from C2-symmetrical bis-epoxides derived from D-mannitol. The described strategy permits access to various configurations of these scaffolds.

Keywords: Carbacycles, aminocyclitols, epoxide opening, ring closing metathesis, Brook rearrangement, reductive amination

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Article Details

Year: 2007
Page: [1 - 13]
Pages: 13
DOI: 10.2174/157017907779981624

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PDF: 13