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Protein & Peptide Letters
ISSN (Print): 0929-8665
ISSN (Online): 1875-5305
VOLUME: 14
ISSUE: 2
DOI: 10.2174/092986607779816050      Price:  $58









tRNase Z

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Author(s): Maria Ceballos and Agustin Vioque
Pages 137-145 (9)
Abstract:
Endonuclease tRNase Z catalyzes the generation of the mature 3 end of tRNA precursors through specific endonucleolytic cleavage. The enzyme has been characterized from organisms representative of all domains of life as well as from organelles, and the crystal structure of three bacterial enzymes has been determined. This review presents an overview of its properties and what is known about its structure, substrate recognition, cleavage site definition, and potential practical applications. Z.
Keywords:
3'-tRNase, RNase Z, tRNA 3' endonuclease, metallo-β -lactamase domain, tRNA processing, tRNase, Trz
Affiliation:
Instituto de Bioquimica Vegetal y Fotosíntesis, Universidad de Sevilla-CSIC, Americo Vespucio 49,41092 Sevilla, Spain.