Abstract
Toxin-antitoxin systems were discovered as plasmid auxiliary maintenance cassettes. In recent years, an increasing amount of structural and functional information has become available about the proteins involved, allowing the understanding of bacterial cell growth inhibition by the toxins on a molecular level. A well-studied TA system is formed by the proteins Kid and Kis, encoded by the parD operon of the Escherichia coli plasmid R1. The toxicity of Kid has been related to its endoribonuclease activity, which is counteracted by binding of the antitoxin Kis at the proposed active site. In this review, the structural studies on the Kid-Kis system are compared to those of three related toxin-antitoxin systems: MazF-MazE, CcdB-CcdA and RelE-RelB.
Keywords: CcdB-CcdA, MazF-MazE, plasmid maintenance, RelE-RelB, ribonuclease
Protein & Peptide Letters
Title: Structure and Function of Bacterial Kid-Kis and Related Toxin-Antitoxin Systems
Volume: 14 Issue: 2
Author(s): Monique B. Kamphuis, Maria Chiara Monti, Robert H. H. van den Heuvel, Juan Lopez-Villarejo, Ramon Diaz-Orejas and Rolf Boelens
Affiliation:
Keywords: CcdB-CcdA, MazF-MazE, plasmid maintenance, RelE-RelB, ribonuclease
Abstract: Toxin-antitoxin systems were discovered as plasmid auxiliary maintenance cassettes. In recent years, an increasing amount of structural and functional information has become available about the proteins involved, allowing the understanding of bacterial cell growth inhibition by the toxins on a molecular level. A well-studied TA system is formed by the proteins Kid and Kis, encoded by the parD operon of the Escherichia coli plasmid R1. The toxicity of Kid has been related to its endoribonuclease activity, which is counteracted by binding of the antitoxin Kis at the proposed active site. In this review, the structural studies on the Kid-Kis system are compared to those of three related toxin-antitoxin systems: MazF-MazE, CcdB-CcdA and RelE-RelB.
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Cite this article as:
Kamphuis B. Monique, Chiara Monti Maria, H. van den Heuvel H. Robert, Lopez-Villarejo Juan, Diaz-Orejas Ramon and Boelens Rolf, Structure and Function of Bacterial Kid-Kis and Related Toxin-Antitoxin Systems, Protein & Peptide Letters 2007; 14 (2) . https://dx.doi.org/10.2174/092986607779816096
DOI https://dx.doi.org/10.2174/092986607779816096 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
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