Recent Patents on Anti-Infective Drug Discovery

Dieter Kabelitz  
Institute of Immunology
Universitätsklinikum Schleswig-Holstein
Campus Kiel
Arnold-Heller-Straße 3
Kiel, D-24105
Germany

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Antibiotic Treatment Strategies for Helicobacter pylori Infection

Author(s): S.M. A. Campo, A. Zullo, C. Hassan and S. Morini

Affiliation: Ospedale Nuovo Regina Margherita, Gastroenterologia ed Endoscopia Digestiva, Via E. Morosini, 30, 00153 Roma–Italy.

Keywords: Antibiotics, Helicobacter pylori, therapy

Abstract:

In the third decade of the Helicobacter pylori era several informations are available on its pathogenetic mechanisms, as well as on therapeutic approaches. A 7-14 day triple or quadruple regimens (proton pump inhibitor together with 2 antibiotics) are currently suggested as first-line treatment, but the success rate following these therapy is constantly decreasing worldwide. Therefore, new drugs are needed to treat such a widespread infection. Several patents of new antibiotics have been claimed in the last 5 years, and some of them showed a very powerful antibacterial activity in vitro, even against clarithromycin and metronidazole resistant strains. Among the new compounds, thienylthiazole derivatives, benzamide derivatives and pyloricidins should be regarded as very promising molecules.

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Article Details

VOLUME: 2
ISSUE: 1
Page: [11 - 17]
Pages: 7
DOI: 10.2174/157489107779561706