A Highly Efficient Low Temperature Modification of the Classical Ullmann Reaction

Author(s): Frederic R. Leroux, Roger Simon, Nathalie Nicod.

Journal Name: Letters in Organic Chemistry

Volume 3 , Issue 12 , 2006

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The efficient synthesis of sterically demanding tetra-substituted biaryls by means of a one-pot threestep low-temperature modification of the classical Ullmann reaction is reported. The major benefit of this methodology lies in the ready synthesis of polybrominated biaryls, which can be subsequently functionalized into various target molecules by means of regioselective halogen/metal permutations.

Keywords: Ullmann reaction, C-C coupling, aryllithium, copper

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Article Details

Year: 2006
Page: [948 - 954]
Pages: 7
DOI: 10.2174/157017806779467979
Price: $65

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