Crotylation of (R)-2,3-Cyclohexylideneglyceraldehyde: A Simple Strategy for the Synthesis of Enantiopure anti-Alzheimer (R)-Arundic Acid

Author(s): Dibakar Goswami, Angshuman Chattopadhyay.

Journal Name: Letters in Organic Chemistry

Volume 3 , Issue 12 , 2006

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Abstract:

(R)-Arundic acid 15 was prepared in a simple manner and with absolute optical purity via Cu and Fe mediated and Luches crotylation of 1 with bromides 6a,b. Co wasnt a good mediator for these crotylation reactions. The stereoselectivity for all crotylations were similar producing mainly 7b, c, besides a small amount of 7a.

Keywords: Alzheimer disease, arundic acid, (R)-2,3-cyclohexylideneglyceraldehyde, crotylation, propargyl alcohol, stereoselectivity, ozonolysis, enantiopurity

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Article Details

VOLUME: 3
ISSUE: 12
Year: 2006
Page: [922 - 925]
Pages: 4
DOI: 10.2174/157017806779468059
Price: $58

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