A series of cholesterylated carboxylic acids L1-L6 as the hepatic targeting ligands were synthesized for gene delivery. The characteristics of those ligands is cholesterylated ones with different spacer lengths with oigo(ethylene glycol) units. We designed two different routes to synthesize L1-L6 from alcohol 3 under mild condition in moderate yield.
Keywords: Cholesterylated carboxylic acid, oligo(ethylene glycols), targeting ligand, gene delivery
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