Synthesis of Cholesterylated Carboxylic Acids with Oligo(Polyethylene Glycols) Units for Gene Delivery

Author(s): Xiaochun Wu, Yong Wu, Li Hai, Ying Bao.

Journal Name: Letters in Organic Chemistry

Volume 3 , Issue 12 , 2006

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A series of cholesterylated carboxylic acids L1-L6 as the hepatic targeting ligands were synthesized for gene delivery. The characteristics of those ligands is cholesterylated ones with different spacer lengths with oigo(ethylene glycol) units. We designed two different routes to synthesize L1-L6 from alcohol 3 under mild condition in moderate yield.

Keywords: Cholesterylated carboxylic acid, oligo(ethylene glycols), targeting ligand, gene delivery

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Article Details

Year: 2006
Page: [911 - 914]
Pages: 4
DOI: 10.2174/157017806779468004
Price: $65

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