Novel One-Pot Synthesis of Amide Derivatives of Methylenebisphosphonate Utilizing the Mesyl Moiety as Leaving Group

Author(s): Jonna Jokiniemi, Markku Ahlgren, Jouko J. Vepsalainen.

Journal Name: Letters in Organic Chemistry

Volume 3 , Issue 12 , 2006

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Abstract:

A novel one-pot synthesis was developed for the preparation of partial amide esters of (dichloromethylene)bisphosphonic acid from readily available tetramethyl ester with good selectivity and purity.

Keywords: Bisphosphonate, amide esters, selective synthesis, mesyl leaving group, amination

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Article Details

VOLUME: 3
ISSUE: 12
Year: 2006
Page: [898 - 900]
Pages: 3
DOI: 10.2174/157017806779467951
Price: $65

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