Abstract
New pseudopeptides possessing C2 symmetry and dihydroxyethylene core derived from (R,R)- tartaric acid and amino esters have been synthesized as potential inhibitors of HIV protease. The amino esters were chosen in order to interact with P1/P1 and P2/P2 subsites of the enzyme. The products were obtained in good yields without noticeable racemization.
Keywords: AIDS, HIV, tartaric acid, C2 symmetry, protease inhibitors, pseudopeptides
Letters in Organic Chemistry
Title: Synthesis of Pseudopeptides Derived from (R,R)-Tartaric Acid as Potential Inhibitors of HIV-Protease
Volume: 3 Issue: 12
Author(s): Jose C. Barros, Joaquim F. M. da Silva, Alexandre R. Calazans, Amilcar Tanuri, Rodrigo de Morais Brindeiro, John S. Williamson and Octavio A.C. Antunes
Affiliation:
Keywords: AIDS, HIV, tartaric acid, C2 symmetry, protease inhibitors, pseudopeptides
Abstract: New pseudopeptides possessing C2 symmetry and dihydroxyethylene core derived from (R,R)- tartaric acid and amino esters have been synthesized as potential inhibitors of HIV protease. The amino esters were chosen in order to interact with P1/P1 and P2/P2 subsites of the enzyme. The products were obtained in good yields without noticeable racemization.
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Cite this article as:
Barros C. Jose, M. da Silva F. Joaquim, Calazans R. Alexandre, Tanuri Amilcar, Brindeiro Rodrigo de Morais, Williamson S. John and Antunes A.C. Octavio, Synthesis of Pseudopeptides Derived from (R,R)-Tartaric Acid as Potential Inhibitors of HIV-Protease, Letters in Organic Chemistry 2006; 3 (12) . https://dx.doi.org/10.2174/157017806779468040
DOI https://dx.doi.org/10.2174/157017806779468040 |
Print ISSN 1570-1786 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6255 |
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