Synthesis and Functionalization of 6,7-Dihydro-[1,4]Dioxino[2,3-d] Pyrimidines

Author(s): Guido Lavecchia, Sabine Berteina-Raboin, Gerald Guillaumet.

Journal Name: Letters in Organic Chemistry

Volume 3 , Issue 12 , 2006

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Abstract:

The cyclization of 4,5-dihydroxy-2-methyl-pyrimidine followed by dibromination and oxidation of the methyl group led to 6,7-dihydro-[1,4]dioxino[2,3-d]pyrimidine-2-carboxaldehyde. This compound underwent different chemical transformations on carbonyl group to synthesize various 2-substituted-6,7- dihydro-[1,4]dioxino[2,3-d]pyrimidines.

Keywords: quantitative deprotection, N-alkylation, 2-dibromomethyl-DDP, modified Harris synthesis, Wittig reaction

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Article Details

VOLUME: 3
ISSUE: 12
Year: 2006
Page: [877 - 881]
Pages: 5
DOI: 10.2174/157017806779468031
Price: $65

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